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Publications

1.     Wonderlick, D. R.; Widom, J. R.; Harms, M. J. “Disentangling contact and ensemble epistasis in a riboswitch”. Biophys. J., 2023, 122, 1600-1612.

2.     Widom, J. R.*, Hoeher, J. E. “Base-Stacking Heterogeneity in RNA Resolved by Fluorescence-Detected Circular Dichroism Spectroscopy”. J. Phys. Chem. Lett., 2022, 13, 8010-8018.

3.     Yadav, R.; Widom, J. R.; Chauvier, A.; Walter, N. G. “An anionic ligand snap-locks a long-range interaction in a magnesium-folded riboswitch”. Nat. Commun., 2022, 13, 207.

4.     Widom, J. R.*; Rai, V.; Rohlman, C. E.; Walter, N. G.* "Versatile Transcription Control based on Reversible dCas9 Binding," RNA, 2019, 25, 1457-1469.1.

5.     Widom, J. R.; Nedialkov, Y. A.; Rai, V.; Hayes, R. L.; Brooks III, C. L.; Artsimovitch, I. A.; Walter, N. G. “Ligand Modulates Cross-Coupling between Riboswitch Folding and Transcriptional Pausing,” Mol. Cell, 2018, 72, 541-555.

6.     Ray, S. R.; Widom, J. R.; Walter, N. G. "Life under the Microscope: Single-Molecule Fluorescence Highlights the RNA World," Invited review for "RNA: From Single Molecule to Medicine" special issue at Chem. Rev.2018, 118, 4120-4155.

7.     Kringle, L.; Sawaya, N.; Widom, J. R.; Adams, C.; Raymer, M. G.; Aspuru-Guzik, A.; Marcus, A. H. "Temperature-Dependent Vibronic Coupling of Cy3 Dimers in Double-Stranded DNA," Featured cover article in J. Chem. Phys.2018, 148, 085101.

8.     Daher, M.; Widom, J. R.; Tay, W.; Walter, N. G“Soft Interactions with Model Crowders and Non-Canonical Interactions with Cellular Proteins Drive RNA Folding”, J. Mol. Biol.2018, 430, 509-523.

9.     Saif, M.; Widom, J. R.; Xu, S.; Abbey, E. R.; Liu, S.; Marcus, A. H. “Electric Dipole Transition Moments and Solvent-Dependent Interactions of Fluorescent Boron-Nitrogen Substituted Indole Derivatives,” J. Phys. Chem. B2015, 119, 7985-7993.

10.     Kahlscheuer, M. L.; Widom, J. R.; Walter, N. G. “Single-Molecule Pull-Down FRET to Dissect the Mechanisms of Biomolecular Machines,” Invited chapter for volume “Structures of Large RNA Molecules and their Complexes,” Method. Enzymol.2015, 558, 539-570.

11.     Le, H. V.; Hawker, D. D.; Wu, R.; Doud, E.; Widom, J. R., Sanishvili, R.; Liu, D.; Kelleher, N. L.; Silverman, R. B. “Design and Mechanism of Tetrahydrothiophene-based GABA Aminotransferase Inactivators,” J. Am. Chem. Soc.2015, 137, 4525-4533.

12.     Karki, K. J.; Widom, J. R.; Seibt, J.; Moody, I.; Lonergan, M C.; Pullerits, T.; Marcus, A. H. “Coherent Two-Dimensional Photocurrent Spectroscopy in a PbS Quantum Dot Photocell,” Nat. Commun.2015, 5, 5869-1-7.

13.     Widom, J. R.; Dhakal, S.; Heinicke, L.; Walter, N. G. “Single-Molecule Tools for Enzymology, Structural Biology, Systems Biology and Nanotechnology: an Update,” Invited review, Arch. Toxicol.2014, 88, 1965-1985.

14.  Raymer, M. R.; Marcus, A. H.; Widom, J. R.; Vitullo, D. “Entangled Photon-Pair Two Dimensional Fluorescence Spectroscopy (EPP-2DFS),” Invited research article for Prof. Michael D. Fayer Festschrift special issue, J. Phys. Chem. B, 2013, 117, 15559-15575.

15.  Karki, K. J.; Torbjornsson, M.; Widom, J. R.; Marcus, A. H.; Pullerits, T. “Digital Cavities and their Potential Applications,” J. Instrum.2013, 8, T05005-1-12.

16.  Widom, J. R.; Perdomo-Ortiz, A.; Lee, W.; Rappoport, D.; Molinski, T. F.; Aspuru-Guzik, A.; Marcus, A. H. “Temperature-Dependent Conformations of a Membrane Supported ‘Zinc Porphyrin Tweezer’ by 2D Fluorescence Spectroscopy,” Invited research article for Prof. John C. Wright Festschrift special issue. J. Phys. Chem. A., 2013, 117, 6171-6184.   

17.  Widom, J. R.; Johnson, N. P.; von Hippel, P. H.; Marcus, A. H. “Solution Conformation of 2-Aminopurine (2-AP) Dinucleotide by Ultraviolet 2D Fluorescence Spectroscopy (UV-2D FS),” Invited research article for special issue on 2D optical coherence spectroscopy, New J. Phys.2013, 15, 025028-1-16.

18.  Widom, J. R.; Rappoport, D.; Perdomo-Ortiz, A.; Thomsen, H.; Johnson, N. P.; von Hippel, P. H.; Aspuru-Guzik, A.; Marcus, A. H. “Electronic Transition Moments of 6-Methyl Isoxanthopterin – a Fluorescent Analogue of the Nucleic Acid Base Guanine,” Nucleic Acids Res., 2013, 41, 995-1004.

19.  Sanders, J. N.; Saikin, S. K.; Mostame, S.; Andrade, X.; Widom, J. R.; Marcus, A. H.; Aspuru-Guzik, A. “Compressed Sensing for Multidimensional Spectroscopy Experiments,”  J. Phys. Chem. Lett.2012, 3, 2697-2702.

20.  Perdomo-Ortiz, A.; Widom, J. R.; Lott, G. A.; Aspuru-Guzik, A.; Marcus, A. H. “Conformation and Electronic Population Transfer in Membrane-Supported Self-Assembled Porphyrin Dimers by 2D Fluorescence Spectroscopy,”  J. Phys. Chem. B2012, 116, 10757-10770.

21.  Lott, G. A.; Perdomo-Ortiz, A.; Utterback, J. K.; Widom, J. R.; Aspuru-Guzik, A.; Marcus, A. H. “Conformation of Self-Assembled Porphyrin Dimers in Liposome Vesicles by Phase-Modulation 2D Fluorescence Spectroscopy,”  Proc. Natl. Acad. Sci. U.S.A.2011, 108, 16521-16526.

22.  Wang, C.; Widom, J.; Petronijevic, F.; Burnett, J. C.; Nuss, J. E.; Bavari, S.; Gussio, R.; Wipf, P. “Synthesis and Biological Evaluation of Inhibitors of Botulinum Neurotoxin Metalloprotease,” Heterocycles2009, 79, 487-520.