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Peer-Reviewed Publications

Helgeson LA, Nolen BJ. (2013) Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP. Elife. 2013 Sep 3;
Wagner AR, Luan Q, Liu SL, Nolen BJ. (2013) Dip1 defines a class of Arp2/3 complex activators that function without preformed actin filaments. Curr Biol. 2013 Oct 21;23(20):1990-8. doi: 10.1016/j.cub.2013.08.029. Epub 2013 Oct 10.

Luan, Qing, Nolen BJ. (2013) Structural basis for regulation of Arp2/3 complex by GMF. Nature Structural & Molecular Biology. 2013 June 2013.

Hetrick B, Han MS, Helgeson LA, Nolen BJ. (2013) Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12

Liu SL, May JR, Helgeson LA, Nolen BJ. (2013) Insertions within the actin core of actin-related protein 3 (Arp3) modulate branching nucleation by Arp2/3 complex. J Biol Chem. 2013 Jan 4;288(1):487-97

Baggett AW, Cournia Z, Han MS, Patargias G, Glass AC, Liu SY, Nolen BJ. (2012) Structural characterization and computer-aided optimization of a small-molecule inhibitor of the Arp2/3 complex, a key regulator of the actin cytoskeleton. ChemMedChem. 2012 Jul;7(7):1286-94.

Liu SL, Needham KM, May JR, Nolen BJ. (2011) Mechanism of a concentration-dependent switch between activation and inhibition of Arp2/3 complex by coronin. J Biol Chem. 2011 May 13;286(19):17039-46. Epub 2011 Mar 21.

Nolen BJ, Tomasevic N, Russell A, Pierce DW, Jia Z, McCormick CD, Hartman J, Sakowicz R, Pollard TD. (2009) Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature. 2009 Aug 20;460(7258):1031-4. Epub 2009 Aug 2.

Nolen, B.J. and Pollard, TD. (2008) Structure and biochemical properties of fission yeast Arp2/3 complex lacking the Arp2 subunit. J Biol Chem. 2008 Sep 26;283(39):26490-8. Epub 2008 Jul 18.

Dalhaimer, P.*, Pollard, T.D., and Nolen, B.J.* (2008) Nucleotide-mediated conformational changes of monomeric actin and Arp3 studied by molecular dynamics simulations. J. Mol. Bio.,376, 166-183.(*contributed equally to this work).

Nolen, B.J. and Pollard, T.D. (2007) Insights into the influence of nucleotides on actin family proteins from seven structures of Arp2/3 complex. Mol. Cell, 26, 449-57.

Nolen, B.J.*, Littlefield, R.S.*, and Pollard, T.D. (2004) Crystal structures of Arp2/3 complex with bound ATP or ADP. Proc. Natl. Acad. Sci. USA , 101, 15627-15632. (*contributed equally to this work).