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Laura Lee McIntyre's research involves early identification and treatment of childhood developmental and behavioral problems, with an emphasis on the multiple systems of care that support children (e.g., families, schools, healthcare). Within this broad framework, three specific lines of research emerge: (1) Parent training, education, and support, (2) transition to kindergarten, and (3) child risk factors and family well-being.

Over the past 20 years, McIntyre's work has focused on understanding and promoting parent and child well-being in families with children with developmental delays or disabilities, including autism spectrum disorder. Her professional background blends the fields of school psychology, special education, and pediatric child clinical psychology and centers on the early identification and treatment of childhood developmental and behavioral problems. Her work emphasizes developing parent–professional partnerships and working with a variety of caregivers who support children. She is especially interested in early intervention and prevention work with families who have young children with developmental problems who are at risk for negative social, emotional, and behavioral outcomes at home and at school. She has funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NIH/NICHD), the National Institute of Mental Health (NIMH), the National Institute of Disability, Independent Living, and Rehabilitation Research (NIDILRR), and the U.S. Department of Education/Institute of Education Sciences (IES) to support this work.